Lions vs Bills
Final: Detroit Lions 31, Buffalo Bills 41. Gridline had Bills by 5.5 (right winner), and its side against the spread covered.
Thu Sep 17, 8:15 PM ET · Highmark Stadium · Week 2, 2026 NFL season
Pregame projection
| Gridline | Vegas | |
|---|---|---|
| Projected margin | Bills by 5.5 | BUF −5.5 |
| Total (Vegas + model adjustments) | 54.3 | 54.5 |
| Total (stats only) | 51.3 | |
| Win probability | Bills 67% · Lions 33% |
- Quarterbacks: Jared Goff (Lions) vs Josh Allen (Bills).
Questions
- How accurate is Gridline?
- Through Nov 12, Gridline has picked 91-45 straight up and 68-63 against the spread in 137 graded 2026 games, with total leans of 1.5+ points at 23-15.
More
- All Week 2 predictions
- Detroit Lions 2026 projections
- Buffalo Bills 2026 projections
- Season board with live odds and the matchup calculator to change the QBs, weather or injuries
Projections are research, not betting advice. Sports betting is not legal in every state. If gambling stops being fun, call or text 1-800-GAMBLER.