Cardinals vs 49ers
Final: Arizona Cardinals 30, San Francisco 49ers 36. Gridline had 49ers by 12.1 (right winner), and its side against the spread did not cover.
Sun Sep 27, 4:05 PM ET · Levi's Stadium · Week 3, 2026 NFL season
Pregame projection
| Gridline | Vegas | |
|---|---|---|
| Projected margin | 49ers by 12.1 | SF −7.5 |
| Total (Vegas + model adjustments) | 49.0 | 48.5 |
| Total (stats only) | 47.4 | |
| Win probability | 49ers 83% · Cardinals 17% |
- Quarterbacks: Jacoby Brissett (Cardinals) vs Brock Purdy (49ers).
Questions
- How accurate is Gridline?
- Through Nov 12, Gridline has picked 91-45 straight up and 68-63 against the spread in 137 graded 2026 games, with total leans of 1.5+ points at 23-15.
More
- All Week 3 predictions
- Arizona Cardinals 2026 projections
- San Francisco 49ers 2026 projections
- Season board with live odds and the matchup calculator to change the QBs, weather or injuries
Projections are research, not betting advice. Sports betting is not legal in every state. If gambling stops being fun, call or text 1-800-GAMBLER.