49ers vs Cardinals
Gridline projects the San Francisco 49ers to beat the Arizona Cardinals 29-17 (82% to win). Vegas has no line posted.
Sun Jan 10, 1:00 PM ET · State Farm Stadium · Week 18, 2026 NFL season
Gridline vs Vegas
| Gridline | Vegas | |
|---|---|---|
| Projected margin | 49ers by 11.7 | no line posted |
| Total (Vegas + model adjustments) | 45.8 | — |
| Total (stats only) | 45.8 | |
| Win probability | Cardinals 18% · 49ers 82% |
- Quarterbacks: Brock Purdy (49ers) vs Gardner Minshew (Cardinals). Backup starting: Gardner Minshew.
Questions
- Who will win 49ers vs Cardinals?
- Gridline projects the San Francisco 49ers to win 29-17, with a 82% chance to win outright.
- How accurate is Gridline?
- Through Nov 12, Gridline has picked 91-45 straight up and 68-63 against the spread in 137 graded 2026 games, with total leans of 1.5+ points at 23-15.
More
- All Week 18 predictions
- San Francisco 49ers 2026 projections
- Arizona Cardinals 2026 projections
- Season board with live odds and the matchup calculator to change the QBs, weather or injuries
Projections are research, not betting advice. Sports betting is not legal in every state. If gambling stops being fun, call or text 1-800-GAMBLER.